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Review
. 1995 Oct;20(10):391-7.
doi: 10.1016/s0968-0004(00)89086-6.

The base excision repair pathway

E Seeberg  1 , L Eide, M Bjørås
Affiliations
Review

The base excision repair pathway

E Seeberg et al. Trends Biochem Sci. 1995 Oct.

Abstract

The base excision repair pathway has evolved to protect cells from the deleterious effects of endogenous DNA damage induced by hydrolysis, reactive oxygen species and other intracellular metabolites that modify DNA base structure. However, base excision repair is also important to resist lesions produced by ionizing radiation and strong alkylating agents, which are similar to those induced by endogenous factors.

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