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Review
. 1995 Oct;20(10):397-401.
doi: 10.1016/s0968-0004(00)89087-8.

Mismatch repair: mechanisms and relationship to cancer susceptibility

R D Kolodner  1
Affiliations
Review

Mismatch repair: mechanisms and relationship to cancer susceptibility

R D Kolodner. Trends Biochem Sci. 1995 Oct.

Abstract

DNA mismatch-repair systems exist that repair mispaired bases formed during DNA replication, genetic recombination and as a result of damage to DNA. Some components of these systems are conserved in prokaryotes and eukaryotes. Genetic defects in mismatch-repair genes play an important role in common cancer-susceptibility syndromes and sporadic cancers.

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