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Review
. 1995 Oct;20(10):412-5.
doi: 10.1016/s0968-0004(00)89090-8.

DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK

S P Jackson  1 , P A Jeggo
Affiliations
Review

DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK

S P Jackson et al. Trends Biochem Sci. 1995 Oct.

Abstract

Two processes involving DNA double-strand breaks (DSBs) are the repair of DNA damage induced by ionizing radiation, and V(D)J recombination, the genomic rearrangement that creates antigen-receptor diversity in vertebrates. Recent evidence indicates that DNA-dependent protein kinase (DNA-PK), which is activated by DNA ends, is a central component of both the DNA DSB repair and V(D)J recombination machineries.

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