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. 1996 Jan 11;379(6561):131-7.
doi: 10.1038/379131a0.

Requirement for Xist in X chromosome inactivation

G D Penny  1 , G F Kay, S A Sheardown, S Rastan, N Brockdorff
Affiliations

Requirement for Xist in X chromosome inactivation

G D Penny et al. Nature. .

Abstract

The Xist gene has been proposed as a candidate for the X inactivation centre, the master regulatory switch locus that controls X chromosome inactivation. So far this hypothesis has been supported solely by indirect evidence. Here we describe gene targeting of Xist, and provide evidence for its absolute requirement in the process of X chromosome inactivation.

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