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. 1996 Jan 18;379(6562):225-32.
doi: 10.1038/379225a0.

Structure and mechanism of DNA topoisomerase II

J M Berger  1 , S J Gamblin, S C Harrison, J C Wang
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Structure and mechanism of DNA topoisomerase II

J M Berger et al. Nature. .

Erratum in

  • Nature 1996 Mar 14;380(6570):179

Abstract

The crystal structure of a large fragment of yeast type II DNA topoisomerase reveals a heart-shaped dimeric protein with a large central hole. It provides a molecular model of the enzyme as an ATP-modulated clamp with two sets of jaws at opposite ends, connected by multiple joints. An enzyme with bound DNA can admit a second DNA duplex through one set of jaws, transport it through the cleaved first duplex, and expel it through the other set of jaws.

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