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Comparative Study
. 1995 Sep;39(9):2128-31.
doi: 10.1128/AAC.39.9.2128.

Resistance of Candida albicans biofilms to antifungal agents in vitro

S P Hawser  1 , L J Douglas
Affiliations
Comparative Study

Resistance of Candida albicans biofilms to antifungal agents in vitro

S P Hawser et al. Antimicrob Agents Chemother. 1995 Sep.

Abstract

Biofilms formed by Candida albicans on small discs of catheter material were resistant to the action of five clinically important antifungal agents as determined by [3H]leucine incorporation and tetrazolium reduction assays. Fluconazole showed the greatest activity, and amphotericin B showed the least activity against biofilm cells. These findings were confirmed by scanning electron microscopy of the biofilms.

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References

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