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Case Reports
. 1995 Nov;34(11):1090-1.
doi: 10.1093/rheumatology/34.11.1090.

Antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis associated with anti-thyroid drug treatment

D D'Cruz  1 , A M Chesser, C Lightowler, M Comer, M J Hurst, L R Baker, A E Raine
Affiliations
Case Reports

Antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis associated with anti-thyroid drug treatment

D D'Cruz et al. Br J Rheumatol. 1995 Nov.

Abstract

Two cases of antineutrophil cytoplasmic antibody (ANCA)-positive vasculitis following treatment with propylthiouracil and carbimazole are described. Both patients had crescentic glomerulonephritis proven by renal biopsy and responded to immunosuppressive therapy and withdrawal of the anti-thyroid drugs. Though systemic vasculitis associated with propylthiouracil is reported, this is the first report to our knowledge of renal biopsy-proven vasculitis associated with either of these drugs.

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