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. 1995;108(2):113-5.
doi: 10.1007/BF01369917.

Genetic polymorphism of the H1 subunit of inter-alpha-trypsin inhibitor

A Harada  1 , K Umetsu, T Suzuki
Affiliations

Genetic polymorphism of the H1 subunit of inter-alpha-trypsin inhibitor

A Harada et al. Int J Legal Med. 1995.

Abstract

Inter-alpha-trypsin inhibitor (ITI) consists of 3 subunits (H1, H2 and L) which are encoded by 3 distinct genes. We attempted to prepare the subunit-specific monoclonal antibodies to identify the subunit carrying ITI polymorphism. Three monoclonal antibodies which were specific against each of these 3 subunits (ITI H1, ITI H2 and ITI L) were selected. ITI types could be detected by anti ITI H1 antibody, but not by anti ITI H2 or anti ITI L antibodies. From the result, it was proved that ITI polymorphism originates from the ITI H1 gene products, therefore we propose to call this system ITI H1 polymorphism.

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