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. 1995 Sep 18;692(1-2):278-82.
doi: 10.1016/0006-8993(95)00637-6.

Quantitative analysis of the olfactory pathway for drug delivery to the brain

R G Thorne  1 , C R Emory, T A Ala, W H Frey 2nd
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Quantitative analysis of the olfactory pathway for drug delivery to the brain

R G Thorne et al. Brain Res. .

Abstract

Following intranasal administration to rats, wheat germ agglutinin-horseradish peroxidase (WGA-HRP) concentrated in the olfactory nerve and glomerular layers of the olfactory bulb resulting in a mean olfactory bulb concentration of 140 nM. A negligible amount of label was detected in the olfactory bulb following intravenous administration of WGA-HRP or intranasal administration of unconjugated HRP. This is the first quantitative assessment of intraneuronal transport of a protein into the brain using the olfactory route.

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