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. 1995 Dec 27;377(3):519-22.
doi: 10.1016/0014-5793(95)01390-3.

Molecular analysis of the sheep cathelin family reveals a novel antimicrobial peptide

M M Mahoney  1 , A Y Lee, D J Brezinski-Caliguri, K M Huttner
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Free article

Molecular analysis of the sheep cathelin family reveals a novel antimicrobial peptide

M M Mahoney et al. FEBS Lett. .
Free article

Abstract

Cathelin-related genes are characterized by the presence of a prepro sequence which is highly conserved both within and between species. 3' RACE analysis on sheep bone marrow RNA, using a primer based on a conserved cathelin family coding region, demonstrated the presence of at least three ovine cathelin-related cDNAs. One of these encodes a novel prepropeptide with a predicted C-terminal cleavage product RGLRRLGRKIAHG-VKKYGPTVLRIIRIAG. The chemically synthesized form of this 29 amino acid peptide is shown to be a thermostable, broad spectrum, bactericidal agent.

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