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. 1995 Aug;25(8):971-3.
doi: 10.1016/0020-7519(94)00212-7.

Serum antibody responses in opisthorchiasis

P S Akai  1 , S Pungpak, W Chaicumpa, V Kitikoon, Y Ruangkunaporn, D Bunnag, A D Befus
Affiliations

Serum antibody responses in opisthorchiasis

P S Akai et al. Int J Parasitol. 1995 Aug.

Abstract

We evaluated an enzyme-linked immunosorbent assay using crude parasite homogenates as a diagnostic test for Opisthorchis viverrini infection in humans. Serum antibody (Ab) responses to O. viverrini adult worm homogenate (AWH) and metacercaria homogenate (MH) were studied in 83 infected residents of an opisthorchiasis-endemic area in Thailand. Elevated levels of Ab persisted for over 1 year following curative treatment with praziquantel, and cross-reactivity to O. viverrini AWH and MH antigens was observed in sera from individuals with other parasitic infections. Serum Ab to crude AWH and MH are therefore unsuitable for immunodiagnosis since they may be non-specific and would not differentiate between ongoing and past infection.

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