Pathogenesis of sepsis with central venous catheter use: alternate locus-related versus central venous catheter-related sepsis

Abstract

Objective: To review literature identifying a central venous catheter (CVC) as either a primary or a secondary source of sepsis.

Data sources: Studies of CVC use in adults, children, and infants from 1968 to 1994.

Study selection: Selection of 10 studies was based on documented distinction between CVC-related and alternate infectious locus-related sepsis.

Data extraction: Abstracted from each study were either total sepsis or colonization rates, as well as the percentages of infection related to the CVC and to alternate infectious loci.

Data synthesis: Percentages of alternate-locus-related sepsis can be two to four times greater than percentages of CVC-related sepsis.

Conclusions: The potential exists for the development of alternate-locus-related sepsis in patients with CVCs. Surveillance measures should reflect this potential.