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. 1994 Nov;1(6):744-6.
doi: 10.1128/cdli.1.6.744-746.1994.

Size variation of the major immunodominant protein of Cowdria ruminantium

A F Barbet  1 , S M Semu, N Chigagure, P J Kelly, F Jongejan, S M Mahan
Affiliations

Size variation of the major immunodominant protein of Cowdria ruminantium

A F Barbet et al. Clin Diagn Lab Immunol. 1994 Nov.

Abstract

An immunodominant response is made to a polypeptide of approximately 32 kDa in animals infected with the rickettsial pathogen Cowdria ruminantium. We show here using cultured strains of the rickettsia from different geographical areas that the apparent size of this polypeptide varies with strain origin. Changes in the primary structure between strains should be considered in the design of vaccines and diagnostic tests based on this antigen.

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