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Clinical Trial
. 1995 Oct;39(3):173-80.
doi: 10.1016/0376-8716(95)01154-9.

Amantadine does not reduce cocaine use or craving in cocaine-dependent methadone maintenance patients

L Handelsman  1 , L Limpitlaw, D Williams, J Schmeidler, P Paris, B Stimmel
Affiliations
Clinical Trial

Amantadine does not reduce cocaine use or craving in cocaine-dependent methadone maintenance patients

L Handelsman et al. Drug Alcohol Depend. 1995 Oct.

Abstract

We tested the efficacy of amantadine to reduce cocaine use or craving in cocaine-dependent methadone maintained patients. Two doses of amantadine (200 mg p.o. daily, n = 16, and 200 mg p.o. bid, n = 21) were tested against placebo, n = 22, in a random assignment, double-blind clinical trial lasting nine weeks. Amantadine was well tolerated. However, neither dose of amantadine was more effective than placebo in reducing cocaine use and craving.

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