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Clinical Trial
. 1996 Jan;46(1):100-3.
doi: 10.1212/wnl.46.1.100.

Pilot trial of immunoglobulin versus plasma exchange in patients with Guillain-Barré syndrome

V Bril  1 , W K Ilse, R Pearce, A Dhanani, D Sutton, K Kong
Affiliations
Clinical Trial

Pilot trial of immunoglobulin versus plasma exchange in patients with Guillain-Barré syndrome

V Bril et al. Neurology. 1996 Jan.

Abstract

We compared intravenous immunoglobulin (IVIG) and plasma exchange (PLEX) in the treatment of 50 patients with Guillain-Barré syndrome (GBS). Standard outcome measures did not differ for the two groups. Sixty-one percent of the PLEX-treated group and 69% of the IVIG-treated group improved by one disability grade at 1 month. The complication rate was higher in the PLEX-treated group. We conclude that the efficacy of IVIG in the treatment of GBS is comparable with that of PLEX and that it can be used safely, although we had a small number of patients. We did not observe a higher relapse rate with IVIG. The usefulness of combination therapy is unknown at this time.

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