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. 1977 Mar;11(3):491-9.
doi: 10.1128/AAC.11.3.491.

Inhibition of initiation, elongation, and termination of eukaryotic protein synthesis by trichothecene fungal toxins

E Cundliffe, J E Davies

Inhibition of initiation, elongation, and termination of eukaryotic protein synthesis by trichothecene fungal toxins

E Cundliffe et al. Antimicrob Agents Chemother. 1977 Mar.

Abstract

The 12,13-epoxytrichothecenes, specific inhibitors of protein synthesis in eukaryotes, can be subdivided further in terms of their mode of action. In addition to the I-type (initiation inhibitors) and E-types (elongation inhibitors), we found that some E-types apparently exhibit inhibition of chain termination at low concentrations. The nature of substituents on C4 may determine the type of inhibitory activity observed.

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References

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