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. 1996 Jan 26;271(5248):505-8.
doi: 10.1126/science.271.5248.505.

Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent

J Linnen  1 , J Wages Jr, Z Y Zhang-Keck, K E Fry, K Z Krawczynski, H Alter, E Koonin, M Gallagher, M Alter, S Hadziyannis, P Karayiannis, K Fung, Y Nakatsuji, J W Shih, L Young, M Piatak Jr, C Hoover, J Fernandez, S Chen, J C Zou, T Morris, K C Hyams, S Ismay, J D Lifson, G Hess, S K Foung, H Thomas, D Bradley, H Margolis, J P Kim
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Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent

J Linnen et al. Science. .

Abstract

An RNA virus, designated hepatitis G virus (HGV), was identified from the plasma of a patient with chronic hepatitis. Extension from an immunoreactive complementary DNA clone yielded the entire genome (9392 nucleotides) encoding a polyprotein of 2873 amino acids. The virus is closely related to GB virus C (GBV-C) and distantly related to hepatitis C virus, GBV-A, and GBV-B. HGV was associated with acute and chronic hepatitis. Persistent viremia was detected for up to 9 years in patients with hepatitis. The virus is transfusion-transmissible. It has a global distribution and is present within the volunteer blood donor population in the United States.

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