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Clinical Trial
. 1995 Sep-Oct;89(5):507-9.
doi: 10.1016/0035-9203(95)90087-x.

Fever in uncomplicated Plasmodium falciparum malaria: randomized double-'blind' comparison of ibuprofen and paracetamol treatment

S Krishna  1 , S Pukrittayakamee, W Supanaranond, F ter Kuile, M Ruprah, T Sura, N J White
Affiliations
Clinical Trial

Fever in uncomplicated Plasmodium falciparum malaria: randomized double-'blind' comparison of ibuprofen and paracetamol treatment

S Krishna et al. Trans R Soc Trop Med Hyg. 1995 Sep-Oct.

Abstract

Fever almost invariably accompanies uncomplicated falciparum malaria. In a randomized, double-'blind' study, we compared a single dose of ibuprofen (10 mg/kg, n = 8) with paracetamol (15 mg/kg, n = 8) for the treatment of fever > 38.5 degrees C due to uncomplicated falciparum malaria. Ibuprofen was significantly more effective than paracetamol in lowering temperatures throughout the first 4.5 h after dosing (P = 0.016) and should be considered as an antipyretic agent in the management of uncomplicated falciparum infections, providing there is no contraindication to its use.

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