doi: 10.1159/000149033.
Effect of azacytidine in SV40-infected BSC-1 cells
- PMID: 85613
- DOI: 10.1159/000149033
Item in Clipboard
Effect of azacytidine in SV40-infected BSC-1 cells
Intervirology.
1979.
Abstract
5-Azacytidine (5-AzaCR) reduced significantly the levels of ribosomal 28S and 18S RNAs in the cytoplasm of uninfected and simian virus 40 (SV40)-infected BSC-1 cells. The percent inhibition of ribosomal RNAs was correlated to both the dose of AzaCR and the time of exposure. In SV40-infected cultures treated with 200 microgram/ml AzaCR, a portion of the total cytoplasmic radioactivity was observed to sediment as 19S and 16S by sucrose gradient analysis. The 19S and 16S peaks represented in part the viral-specific RNA species. This result was due to the drastic reduction (70--75%) of ribosomal RNAs in the cytoplasm of infected cultures.
Similar articles
-
Azapyrimidine analogues: inhibition of viral DNA synthesis and protein synthesis in SV40 infected BSC-1 cells.In Vitro Cell Dev Biol. 1988 Nov;24(11):1114-20. doi: 10.1007/BF02620813. In Vitro Cell Dev Biol. 1988. PMID: 2461357
-
Effect of 5-azacytidine on cytoplasmic ribosomal and messenger ribonucleic acids in BSC-1 cells.Antimicrob Agents Chemother. 1979 Feb;15(2):235-9. doi: 10.1128/AAC.15.2.235. Antimicrob Agents Chemother. 1979. PMID: 85433 Free PMC article.
-
Methylated simian virus 40-specific RNA from nuclei and cytoplasm of infected BSC-1 cells.Proc Natl Acad Sci U S A. 1975 Jun;72(6):2012-6. doi: 10.1073/pnas.72.6.2012. Proc Natl Acad Sci U S A. 1975. PMID: 166375 Free PMC article.
-
RNAs of simian virus 40 in productively infected monkey cells: kinetics of formation and decay in enucleate cells.Proc Natl Acad Sci U S A. 1975 Jul;72(7):2587-91. doi: 10.1073/pnas.72.7.2587. Proc Natl Acad Sci U S A. 1975. PMID: 170607 Free PMC article.
-
Ability of nonpermissive mouse cells to express a simian virus 40 late function(s).J Virol. 1981 Jun;38(3):940-51. doi: 10.1128/JVI.38.3.940-951.1981. J Virol. 1981. PMID: 6264164 Free PMC article.
Cited by
-
Azapyrimidine analogues: inhibition of viral DNA synthesis and protein synthesis in SV40 infected BSC-1 cells.In Vitro Cell Dev Biol. 1988 Nov;24(11):1114-20. doi: 10.1007/BF02620813. In Vitro Cell Dev Biol. 1988. PMID: 2461357
-
Effect of azacytidine on Simian Virus 40 nucleoprotein complexes.Antimicrob Agents Chemother. 1979 Nov;16(5):667-73. doi: 10.1128/AAC.16.5.667. Antimicrob Agents Chemother. 1979. PMID: 93427 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
