Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 Apr;20(3):859-68.
doi: 10.1002/art.1780200316.

Connective tissue activation. XI. Stimulation of glycosaminoglycan and DNA formation by a platelet factor

C W Castor, J C Ritchie, M E Scott, S L Whitney

Connective tissue activation. XI. Stimulation of glycosaminoglycan and DNA formation by a platelet factor

C W Castor et al. Arthritis Rheum. 1977 Apr.

Abstract

This report describes a small basic protein found in human platelets which stimulates hyaluronic acid formation, glucose uptake, and lactate formation in several types of human connective tissue cells. In addition, it stimulates in incorporation of [3H] methyl thymidine into DNA in human synovial cell cultures. This platelet factor (connective tissue activating peptide-II, CTAP-III) clearly differs form CTAP-I, found in human lymphocytes, and may play a role as a mediator of the inflammatory process.

PubMed Disclaimer

Publication types

LinkOut - more resources