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Review
. 1995 Oct;3(10):401-4.
doi: 10.1016/s0966-842x(00)88987-8.

Prospects for new vaccines against tuberculosis

I M Orme  1
Affiliations
Review

Prospects for new vaccines against tuberculosis

I M Orme. Trends Microbiol. 1995 Oct.

Abstract

The spectacular failure of the existing bacille Calmette-Guérin (BCG) vaccine in recent tuberculosis-control trials has prompted a search for potential replacements. Imaginative approaches currently under development include the modulation of BCG by the production of auxotrophic mutants or cytokine-secreting recombinants, and the development of subunit vaccines based on the major proteins of Mycobacterium tuberculosis.

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