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. 1996 Feb 1;56(3):448-51.

A new member of the proprotein convertase gene family (LPC) is located at a chromosome translocation breakpoint in lymphomas

J Meerabux  1 , M L Yaspo, A J Roebroek, W J Van de Ven, T A Lister, B D Young
Affiliations
  • PMID: 8564950

A new member of the proprotein convertase gene family (LPC) is located at a chromosome translocation breakpoint in lymphomas

J Meerabux et al. Cancer Res. .

Abstract

A new member of the proprotein convertase gene family (LPC) has been identified at a chromosome translocation breakpoint occurring in a high grade lymphoma. The translocation t(11;14)(q23;q32) has been molecularly cloned and shown to be the result of a fusion between an intron in the 3' -untranslated region of LPC with a sequence close to the switch region S gamma 4 of the IGH locus. The LPC gene encodes a protein of 785 amino acids with substantial homology to furin and the other members of the proprotein convertase family and represents a novel target for chromosome translocation and subsequent deregulation.

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