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Clinical Trial
. 1995 Apr-Jun;49(2):111-5.

[Helicobacter pylori eradication heals the duodenal ulcer. Randomized, simple, and controlled study with omeprazole]

[Article in Spanish]
R Piñero  1 , M Pacheco, M Urrestarazu, N Serrano, R Olavarría, J R Poleo
Affiliations
  • PMID: 8566681
Clinical Trial

[Helicobacter pylori eradication heals the duodenal ulcer. Randomized, simple, and controlled study with omeprazole]

[Article in Spanish]
R Piñero et al. G E N. 1995 Apr-Jun.

Abstract

60 patients with Helicobacter pylori (Hp) infection and duodenal ulcer (DU) were randomized to received either: I) Two weeks of bismuth subcitrate, metronidazole and amoxicillin (TG) or II) Omeprazole for four weeks (OG). Endoscopy and antral biopsies were done at entry and four weeks after treatment, control endoscopy was performed 2-4-8 and 12 weeks after inclusion in the trial. Healing was similar in both groups at two four weeks. At twelve weeks DU recurred in OG 65% vs 13.36% in TG and Hp infection was present. Our results showed that Hp eradication healed DU in a similar rate than Omeprazole providing further evidence of a causal link between Hp infection and duodenal ulcer.

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