Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 Feb;18(2):111-4.
doi: 10.1136/gut.18.2.111.

Effects of oral calcium gluconate on gastric acid secretion and serum gastrin concentration in man

M J Brodie, P C Ganguli, A Fine, T J Thomson

Effects of oral calcium gluconate on gastric acid secretion and serum gastrin concentration in man

M J Brodie et al. Gut. 1977 Feb.

Abstract

A single oral dose of 4-46 mmol calcium gluconate at pH 5-6 was administered intragastrically to 15 male volunteers without gastrointestinal disease. There was a significant rise in acid output from 30-90 minutes after the calcium was given compared with the basal hourly collection. The serum gastrin level 30 minutes after calcium administration was significantly raised, but no correlation could be demonstrated between the acid and gastrin responses. Serum calcium levels were unchanged throughout. An equimolar dose of magnesium sulphate had no such effects. This study suggests that the intragastric administration of calcium results in independent release of gastric acid and gastrin from the gastric mucosa.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Gastroenterology. 1950 Sep;16(1):172-80 - PubMed
    1. J Physiol. 1972 Jan;220(2):499-510 - PubMed
    1. Nat New Biol. 1972 Nov 29;240(100):150-2 - PubMed
    1. Surgery. 1972 Jul;72(1):60-7 - PubMed
    1. Gastroenterology. 1973 Jun;64(6):1168-84 - PubMed

LinkOut - more resources