Determination of prenatal sex ratio in man

Abstract

The sex of a conceptus at the early embryonic state was diagnosed in 1000 induced abortions. Specimens were obtained from women who terminated their pregnancies within 12 menstrual weeks on socio-economic indications. By making use of the triple checking procedures, such as the karyotypic analysis of Giemsa-stained slides, the fluorescent Y chromosome analysis and the Y-body test in interphase nuclei, the sex ratio was determined as 106.6 (516 males/484 females). The sex distribution in the chromosomally normal embryos was 481 in males to 448 in females; that gave the ratio of 107.4. A slight excess of males was already present at his stage of pregnancy. When the ratios were calculated in relation to the maternal age, the lower sex ratio was noted for embryos born to mothers over 30 years. Taking a Y-bearing embryo as male, the ratio in 71 chromosomally aberrant embryos was 97.2 (35 males/36 females). The sex ratio in the cases of chromosome abnormalities was not statistically different from that of thenormal embryos.