Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 May;59(5):810-8.
doi: 10.1172/JCI108703.

Quantitative determination of antibody to capsular polysaccharide in infection with type III strains of group B Streptococcus

C J Baker, D L Kasper, Tager IRAB, A Paredes, S Alpert, W M McCormack, D Goroff

Quantitative determination of antibody to capsular polysaccharide in infection with type III strains of group B Streptococcus

C J Baker et al. J Clin Invest. 1977 May.

Abstract

The development of antibody in response to invasive infection with type III strains of group B Streptococcus was studied in sera from 31 infants and 4 adults by means of a quantitative radioactive antigen-binding assay. Low concentrations of antibody were consistently found in the acute sera of patients who developed clinical illness. Although adults with puerperal sepsis and infants with bone or joint infection uniformly demonstrated significant rises in serum antibody concentration after recovery, much lower levels of antibody were detected in convalescent sera from infants recovering from meningitis or sepsis. The median antibody concentration in sera from 43 parturients with type III strains of group B Streptococcus isolated from vaginal cultures whose neonates failed to develop symptomatic disease was significantly greater than that in sera from 29 mothers of infants with invasive, type III, group B streptococcal infection. Study of paired maternal and cord sera demonstrated a significant correlation between the antibody concentration in a mother's serum and that in her neonate.

PubMed Disclaimer

References

    1. Arch Biochem Biophys. 1958 Dec;78(2):306-18 - PubMed
    1. J Infect Dis. 1958 Nov-Dec;103(3):239-62 - PubMed
    1. Acta Pathol Microbiol Scand. 1958;43(3):305-9 - PubMed
    1. JAMA. 1974 Nov 25;230(8):1158-60 - PubMed
    1. N Engl J Med. 1974 May 30;290(22):1216-20 - PubMed

Publication types

Substances