Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Jan 5;39(1):143-8.
doi: 10.1021/jm950625l.

3-Benzisothiazolylpiperazine derivatives as potential atypical antipsychotic agents

H R Howard  1 , J A Lowe 3rd, T F Seeger, P A Seymour, S H Zorn, P R Maloney, F E Ewing, M E Newman, A W Schmidt, J S Furman, G L Robinson, E Jackson, C Johnson, J Morrone
Affiliations

3-Benzisothiazolylpiperazine derivatives as potential atypical antipsychotic agents

H R Howard et al. J Med Chem. .

Abstract

A series of substituted phenethyl derivatives of 3-benzisothiazolylpiperazine incorporating potent D2 and 5-HT2A antagonist activity was investigated as an approach to a novel atypical antipsychotic agent. The in vitro profile of 8e from this series is a combination of D2 receptor affinity comparable to the typical antipsychotic agent haloperidol and a 5-HT2A/D2 ratio comparable to the atypical agent clozapine. In vivo 8e possesses activity consistent with an efficacious antipsychotic agent with less tendency to induce extrapyramidal side effects in man.

PubMed Disclaimer

MeSH terms

LinkOut - more resources