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Comparative Study
. 1996 Jan 23;93(2):548-53.
doi: 10.1073/pnas.93.2.548.

Population dynamics of flaviviruses revealed by molecular phylogenies

P M Zanotto  1 , E A Gould, G F Gao, P H Harvey, E C Holmes
Affiliations
Comparative Study

Population dynamics of flaviviruses revealed by molecular phylogenies

P M Zanotto et al. Proc Natl Acad Sci U S A. .

Abstract

The phylogeny of 123 complete envelope gene sequences was reconstructed in order to understand the evolution of tick- and mosquito-borne flaviviruses. An analysis of phylogenetic tree structure reveals a continual and asymmetric branching process in the tick-borne flaviviruses, compared with an explosive radiation in the last 200 years in viruses transmitted by mosquitoes. The distinction between these two viral groups probably reflects differences in modes of dispersal, propagation, and changes in the size of host populations. The most serious implication of this work is that growing human populations are being exposed to an expanding range of increasingly diverse viral strains.

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Comment in

  • Evolving virus plagues.
    Holland JJ. Holland JJ. Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):545-6. doi: 10.1073/pnas.93.2.545. Proc Natl Acad Sci U S A. 1996. PMID: 8570592 Free PMC article. No abstract available.

References

    1. Experientia. 1993 Sep 15;49(9):802-5 - PubMed
    1. Virology. 1993 Nov;197(1):216-24 - PubMed
    1. J Theor Biol. 1993 Sep 7;164(1):65-83 - PubMed
    1. J Gen Virol. 1994 Jan;75 ( Pt 1):65-75 - PubMed
    1. Mol Biol Evol. 1986 Sep;3(5):418-26 - PubMed

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