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Comparative Study
. 1996 Jan 23;93(2):723-7.
doi: 10.1073/pnas.93.2.723.

Channel behavior in a gamma-aminobutyrate transporter

J N Cammack  1 , E A Schwartz
Affiliations
Comparative Study

Channel behavior in a gamma-aminobutyrate transporter

J N Cammack et al. Proc Natl Acad Sci U S A. .

Abstract

Current produced by a gamma-aminobutyrate (GABA) transporter stably transfected into a mammalian cell line was observed in cell-attached and excised membrane patches. When GABA was absent, a fraction of the transporters produced cation-permeable channels. When GABA plus Na+ was on either side of the membrane, the majority of transporters produced a high-frequency current noise attributed to the movement of ions in an occluded pore.

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References

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