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. 1995 Nov;50(11):736-40.

[The biomimetic oxidation of propiverine hydrochloride and 1-methyl-4-piperidylbenzilate]

[Article in German]
L Fröhlich  1 , B Pietzyk, B Göber
Affiliations
  • PMID: 8570671

[The biomimetic oxidation of propiverine hydrochloride and 1-methyl-4-piperidylbenzilate]

[Article in German]
L Fröhlich et al. Pharmazie. 1995 Nov.

Abstract

The reaction of propiverinhydrochloride (1) and 1-methyl-4-piperidyl benzilate (2) with the biomimetic system manganese(III)-5,10,15,20-tetrakis(pentafluorophenyl)porphyrin chloride (MnTPFPPCl)/pyridine/hydrogen peroxide affords unchanged 1 and 2 and 15 potential metabolites, which were isolated and identified. These compounds are products of cleavage of the ester bond, of O-dealkylation, aromatic oxidation, respectively of decarboxylation, demethylation, and N-oxidation, Products were identified by TLC, UV, and MS in comparison with authentic samples. Thereby we found a nearly conformity with rat metabolism.

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