Review
[Genetic mechanism of human sex differentiation]
[Article in
French]
Affiliations
- PMID: 8570983
Item in Clipboard
Review
[Genetic mechanism of human sex differentiation]
[Article in
French]
Rev Med Brux.
1995 Dec.
Abstract
The genetic mechanism controlling sexual differentiation had remained unknown for a long time. Karyotype analysis of sex-inverted patients or individuals with ambiguous sexual differentiation has enabled the localization and identification of genes involved. It is currently known that the SRY gene is responsible for the initiation of a cascade reaction leading to male differentiation of the primitive gonad. SRY is a +/- 820 base pairs gene located on the small arm of the Y chromosome, more precisely within the 1A1 alpha sub-segment. Although a few other genes are known to be involved in the downstream regulation of SRY, their precise mode of action is yet unknown.
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