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. 1996 Jan;174(1 Pt 1):126-31.
doi: 10.1016/s0002-9378(96)70384-8.

Tumor angiogenesis: an independent prognostic parameter in cervical cancer

G L Bremer  1 , A T Tiebosch, H W van der Putten, H J Schouten, J de Haan, J W Arends
Affiliations

Tumor angiogenesis: an independent prognostic parameter in cervical cancer

G L Bremer et al. Am J Obstet Gynecol. 1996 Jan.

Abstract

Objective: The purpose of this study was to investigate whether the intensity of tumor angiogenesis, expressed as microvessel density, is a parameter predicting the probability of lymph node metastasis and survival in patients with cervical cancer stages IB and IIA.

Study design: In a retrospective study of 114 patients with cervical cancer stages IB and IIA, microvessel density, lymph node status, and several other prognostic parameters were correlated with disease-free survival by a multivariate analysis according to Cox proportional-hazards model.

Results: There was a significant difference in mean microvessel density between tumors with and without pelvic lymph node metastasis (p = 0.002). Both microvessel density (vessels per square millimeter of stroma). (p = 0.05) and pelvic lymph node metastasis (p = 0.007) correlated significantly and independently with disease-free survival.

Conclusion: This study demonstrates that microvessel density is an independent prognostic parameter for disease-free survival in patients with cervical cancer stages Ib and IIa.

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