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. 1996 Jan;55(1):25-9.
doi: 10.1136/ard.55.1.25.

Association of hand and knee osteoarthritis: evidence for a polyarticular disease subset

R Hirsch  1 , M Lethbridge-Cejku, W W Scott Jr, R Reichle, C C Plato, J Tobin, M C Hochberg
Affiliations

Association of hand and knee osteoarthritis: evidence for a polyarticular disease subset

R Hirsch et al. Ann Rheum Dis. 1996 Jan.

Erratum in

  • Ann Rheum Dis 1996 Apr;55(4):272

Abstract

Objective: To examine the association between hand and knee osteoarthritis (OA) in a community based population.

Methods: Radiographs of 695 participants aged > or = 40 years in the Baltimore Longitudinal Study of Aging were read for changes of OA, using Kellgren-Lawrence grade > or = 2 as the case definition.

Results: Logistic regression analyses, adjusting for age, gender and body mass index, revealed a significant association between OA in the knee and the following joint groups: distal and proximal interphalangeal (DIP, PIP) and Hand2 (OA in two or more hand joint groups) for grade 2-4 and grade 3-4 disease, and the first carpometacarpal (CMC1) joint for grade 3-4 disease.

Conclusion: There is an association between OA in hand sites and the knee. The strength of the associations increases with increasing disease severity. For the PIP site, there is a trend toward increasing strength of association for increasing numbers of affected joints and bilateral disease.

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