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. 1996 Jan 5;218(1):40-4.
doi: 10.1006/bbrc.1996.0008.

Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation?

T E Bates  1 , A Loesch, G Burnstock, J B Clark
Affiliations

Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation?

T E Bates et al. Biochem Biophys Res Commun. .

Abstract

In this article we demonstrate the immunocytochemical localization of nitric oxide synthase in mitochondria isolated from heart, skeletal muscle, and kidney, using a monoclonal antibody directed against the endothelial form of nitric oxide synthase. The possibility that mitochondrially located nitric oxide synthase is a ubiquitous regulator of mitochondrial oxidative phosphorylation in mammalian cells is discussed.

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