Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 Apr;24(2):119-20.

Enkephalins inhibit intestinal motility: mode of action

P Mitznegg, W Domschke, W Sprügel, S Domschke, N Subramanian, E Wünsch, L Moroder, L Demling
  • PMID: 857559

Enkephalins inhibit intestinal motility: mode of action

P Mitznegg et al. Acta Hepatogastroenterol (Stuttg). 1977 Apr.

Abstract

In the guinea pig isolated terminal ileum the opioid pentapeptides, methionine-enkephalin and leucine-enkephalin, dose-dependently inhibit contractile responses induced by electrical field stimulation releasing endogenous acetylcholine, and by specific noncholinergic compounds including histamine, barium chloride, and beta-acetyl-digoxin. Tissue levels of cAMP and cGMP remain unchanged. We conclude that enkephalins exert their effects by a direct action at or within the muscle cell and may play a physiological role in the local control of the gut smooth muscle motility.

PubMed Disclaimer