Review
doi: 10.1016/s0074-7696(08)61235-8.
Scaffold/matrix-attached regions: structural properties creating transcriptionally active loci
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- PMID: 8575884
- DOI: 10.1016/s0074-7696(08)61235-8
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Review
Scaffold/matrix-attached regions: structural properties creating transcriptionally active loci
Int Rev Cytol.
1995.
Abstract
The expression characteristics of the human interferon-beta gene, as part of a long stretch of genomic DNA, led to the discovery of the putative domain bordering elements. The chromatin structure of these elements and their surroundings was determined during the process of gene activation and correlated with their postulated functions. It is shown that these "scaffold-attached regions" (S/MAR elements) have some characteristics in common with and others distinct from enhancers with which they cooperate in various ways. Our model of S/MAR function will focus on their properties of mediating topological changes within the respective domain.
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