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Review
. 1995 Jul;74(1):449-53.

Resistance to activated protein C and factor V Leiden as risk factors for venous thrombosis

R M Bertina  1 , P H Reitsma, F R Rosendaal, J P Vandenbroucke
Affiliations
  • PMID: 8578504
Review

Resistance to activated protein C and factor V Leiden as risk factors for venous thrombosis

R M Bertina et al. Thromb Haemost. 1995 Jul.

Abstract

The recent discovery of the factor V Leiden mutation as the molecular defect in the large majority of APC-resistant individuals, has drastically changed our view on familial thrombophilia and it has contributed to a better understanding of the interaction of genetic and environmental risk factors. It has offered firm support for the view that venous thrombosis is a multifactorial disease and that the risk of thrombosis will increase as the number of genetic and/or environmental risk factors increases.

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