[Effect of chronic administration of carbon tetrachloride on turnover of individual RNA fractions in rat liver tissue]
[Article in
Russian]
- PMID: 857968
Item in Clipboard
[Effect of chronic administration of carbon tetrachloride on turnover of individual RNA fractions in rat liver tissue]
[Article in
Russian]
Biull Eksp Biol Med.
1977 Apr.
Abstract
During the carbon tetrachloride treatment of rats (for 24 weeks) the 5-H3-uridine content and incorporation into different rat liver RNA fractions after a short-term exposure of labeled precursor were studied. These fractions were obtained by preparative 2.5% polyacrylamide gel electrophoresis from the nuclear and cytoplasmic RNA extracted by thermal phenol fractionation. CCl4 administration resulted in a decrease in the level of transfer and ribosomal RNAs in the rat liver. Chronic CCl4 treatment led to disturbances of the turnover simultaneousness of different components of rapidly labled RNA.
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