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. 1977 Apr;83(4):423-5.

[Effect of chronic administration of carbon tetrachloride on turnover of individual RNA fractions in rat liver tissue]

[Article in Russian]
S D Ivanov, L A Voronova, M A Pirozhkov
  • PMID: 857968

[Effect of chronic administration of carbon tetrachloride on turnover of individual RNA fractions in rat liver tissue]

[Article in Russian]
S D Ivanov et al. Biull Eksp Biol Med. 1977 Apr.

Abstract

During the carbon tetrachloride treatment of rats (for 24 weeks) the 5-H3-uridine content and incorporation into different rat liver RNA fractions after a short-term exposure of labeled precursor were studied. These fractions were obtained by preparative 2.5% polyacrylamide gel electrophoresis from the nuclear and cytoplasmic RNA extracted by thermal phenol fractionation. CCl4 administration resulted in a decrease in the level of transfer and ribosomal RNAs in the rat liver. Chronic CCl4 treatment led to disturbances of the turnover simultaneousness of different components of rapidly labled RNA.

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