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Review
. 1995 Dec;16(12):595-603.
doi: 10.1016/0167-5699(95)80083-2.

Immunosuppressive retroviral peptides: cAMP and cytokine patterns

S Haraguchi  1 , R A Good, N K Day
Affiliations
Review

Immunosuppressive retroviral peptides: cAMP and cytokine patterns

S Haraguchi et al. Immunol Today. 1995 Dec.

Abstract

The mechanism(s) by which retroviral proteins exert immunosuppressive influences has remained enigmatic. Here, Soichi Haraguchi, Robert Good and Noorbibi Day propose that induction of intracellular cAMP by a synthetic, immunosuppressive, retroviral envelope peptide causes a shift in the cytokine balance, leading to suppression of cell-mediated immunity by upregulation of interleukin 10 (IL-10) and downregulation of IL-2, IL-12 and tumor necrosis factor alpha production. This may be a crucial step towards generation of immune dysfunction.

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