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. 1995 Oct;9(5):603-5.
doi: 10.1007/BF00860949.

von Willebrand factor and factor XIII in children with Henoch-Schonlein purpura

D De Mattia  1 , R Penza, P Giordano, G C Del Vecchio, G Aceto, M Altomare, F Schettini
Affiliations

von Willebrand factor and factor XIII in children with Henoch-Schonlein purpura

D De Mattia et al. Pediatr Nephrol. 1995 Oct.

Abstract

levels of von Willebrand factor antigen (vWf:Ag) and factor XIII activity (F XIII) were studied in relation to the severity of clinical symptoms (scored from 0 to 3) and to immunological parameters [IgA, C3, C4, and circulating immune complexes (CIC)] in 16 children (7 males, 9 females, aged 3-11 years) with Henoch-Schonlein purpura (HSP) at presentation. vWf:Ag was increased in 7 patients, F XIII activity was decreased in 6. In all children we found high levels of IgA, while C3 and C4 levels were normal; CIC were elevated in 11. vWf:Ag correlated with clinical score and with IgA and CIC, probably as a result of immune-mediated endothelial cell damage. The haemostatic alterations observed in HSP are important for understanding the pathophysiology of the disease.

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References

    1. Pediatr Rev. 1992 Apr;13(4):130-7 - PubMed
    1. Lancet. 1988 May 28;1(8596):1203-4 - PubMed
    1. Clin Pediatr (Phila). 1983 Mar;22(3):185-7 - PubMed
    1. Thromb Haemost. 1984 Jul 29;51(3):408 - PubMed
    1. Acta Paediatr Scand. 1977 May;66(3):273-7 - PubMed

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