Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1995 Dec;4(12):2625-8.
doi: 10.1002/pro.5560041222.

Protein recognition of ammonium cations using side-chain aromatics: a structural variation for secondary ammonium ligands

A R Raine  1 , C C Yang, L C Packman, S A White, F S Mathews, N S Scrutton
Affiliations

Protein recognition of ammonium cations using side-chain aromatics: a structural variation for secondary ammonium ligands

A R Raine et al. Protein Sci. 1995 Dec.

Abstract

A model for the structure of dimethylamine dehydrogenase was generated using the crystal coordinates of trimethylamine dehydrogenase. Substrate is bound in trimethylamine dehydrogenase by cation-pi bonding, but modeling of dimethylamine dehydrogenase suggests that secondary amines are bound by a mixture of cation-pi and conventional hydrogen bonding. In dimethylamine dehydrogenase, binding is orientationally more specific and distinct from those proteins that bind tertiary and quaternary amine groups.

PubMed Disclaimer

References

    1. Science. 1991 Aug 23;253(5022):872-9 - PubMed
    1. FEBS Lett. 1986 Jul 28;203(2):139-43 - PubMed
    1. Protein Sci. 1994 Oct;3(10):1889-92 - PubMed
    1. Biochemistry. 1995 Feb 28;34(8):2584-91 - PubMed
    1. J Biol Chem. 1989 Jul 15;264(20):11887-92 - PubMed

Publication types

Substances