The development of prostatic adenocarcinoma in Nb rats following prolonged sex hormone administration
- PMID: 858144
Item in Clipboard
The development of prostatic adenocarcinoma in Nb rats following prolonged sex hormone administration
Cancer Res.
1977 Jun.
Abstract
The low spontaneous incidence of grossly recognizable adenocarcinomas of the dorsal lobe of the prostate in Nb rats over 13 months old (0.45%) was increased to 18.38% in 130 rats by prolonged treatment with pellets of suitable sex hormones. Although testosterone propionate alone was effective, if the testosterone propionate was combined with treatment by estrone carcinomas of the prostate occurred after a shorter interval. Tumors tended to metastasize and transplanted readily, and all were autonomous, with a single exception that exhibited the growth pattern of a typical estrogen-dependent tumor.
Similar articles
-
Production of Nb rat carcinoma of the dorsal prostate and response of estrogen-dependent transplants to sex hormones and tamoxifen.Cancer Res. 1980 Oct;40(10):3547-50. Cancer Res. 1980. PMID: 7438041
-
Hormonal control of growth and progression in tumors of Nb rats and a theory of action.Cancer Res. 1977 Jan;37(1):82-94. Cancer Res. 1977. PMID: 830424
-
Sex steroids as a cause of adenocarcinoma of the dorsal prostate in Nb rats, and their influence on the growth of transplants.Oncology. 1977;34(3):138-41. doi: 10.1159/000225207. Oncology. 1977. PMID: 917444
-
Prostate carcinoma of the Nb rat in relation to hormones.Int Rev Exp Pathol. 1982;23:113-59. Int Rev Exp Pathol. 1982. PMID: 7045013 Review. No abstract available.
-
Multistage prostate carcinogenesis: the role of hormones.Princess Takamatsu Symp. 1991;22:109-23. Princess Takamatsu Symp. 1991. PMID: 1844235 Review.
Cited by
-
Isolation and analysis of discreet human prostate cellular populations.Differentiation. 2016 Apr-Jun;91(4-5):139-51. doi: 10.1016/j.diff.2015.10.013. Epub 2015 Nov 3. Differentiation. 2016. PMID: 26546040 Free PMC article. Review.
-
Hormones and prostate carcinogenesis: Androgens and estrogens.J Carcinog. 2011;10:33. doi: 10.4103/1477-3163.90678. Epub 2011 Dec 8. J Carcinog. 2011. PMID: 22279418 Free PMC article.
-
Immunobiology and therapeutic manipulation of heterotransplanted Nb rat prostatic adenocarcinoma. Chemotherapy of autonomous tumor, 102 Pr, heterotransplanted into congenitally athymic (nude) mice and syngeneic Nb rats.Cancer Chemother Pharmacol. 1979;3(3):167-70. doi: 10.1007/BF00262417. Cancer Chemother Pharmacol. 1979. PMID: 118827
-
Quantified gene expression levels for phase I/II metabolizing enzyme and estrogen receptor levels in benign prostate from cohorts designated as high-risk (UK) versus low-risk (India) for adenocarcinoma at this organ site: a preliminary study.Asian J Androl. 2010 Mar;12(2):203-14. doi: 10.1038/aja.2009.71. Epub 2009 Nov 23. Asian J Androl. 2010. PMID: 19935673 Free PMC article.
-
Testosterone treatment is a potent tumor promoter for the rat prostate.Endocrinology. 2014 Dec;155(12):4629-33. doi: 10.1210/en.2014-1688. Epub 2014 Sep 23. Endocrinology. 2014. PMID: 25247471 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources