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Clinical Trial
. 1995 May-Jun;131(3):349-54.

[Treatment of acute poisoning caused by carbamazepine, digoxin, and acetylsalicylic acid, with repeated doses of activated charcoal]

[Article in Spanish]
M A Montoya-Cabrera  1 , P Escalante-Galindo, J M Sauceda-García, L M Márquez-Enríquez, H González-Cabello, E Flores-Alvarez
Affiliations
  • PMID: 8582575
Clinical Trial

[Treatment of acute poisoning caused by carbamazepine, digoxin, and acetylsalicylic acid, with repeated doses of activated charcoal]

[Article in Spanish]
M A Montoya-Cabrera et al. Gac Med Mex. 1995 May-Jun.

Abstract

Twelve pediatric patients with acute poisonings caused by carbamazepine, digoxin and acetylsalicylic acid were treated with multiple doses of activated charcoal combined with a saline cathartic (adsorption surface of activated charcoal nearly 950 m2/g). This procedure was effective to shorten the plasmatic levels of the drugs, besides the clinical improvement of the poisoned patients. The average initial and final levels of the drugs were: carbamazepine 21.64 and 0.9 micrograms/ml (lowering 95.81%, p < 0.05), digoxin 5.14 and 1.1 ng/ml (lowering 78.6%, P < 0.05) and acetylsalicylic acid 418.5 and 57.5 micrograms/ml, respectively, (lowering 86.3%, p < 0.05). These results suggest the usefulness of activated charcoal in the clearance of the four overdosed drugs.

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