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Case Reports
. 1995 Jul;10(7):1864-5.
doi: 10.1093/oxfordjournals.humrep.a136193.

Successful treatment of an advanced interstitial pregnancy by sequential systemic and local administration of methotrexate

A Hoek  1 , F J Broekmans, R H Verheijen, R Schats
Affiliations
Case Reports

Successful treatment of an advanced interstitial pregnancy by sequential systemic and local administration of methotrexate

A Hoek et al. Hum Reprod. 1995 Jul.

Abstract

A patient is presented with an advanced interstitial pregnancy, diagnosed by transvaginal ultrasound and confirmed by laparoscopy. Amenorrhoea at the time of diagnosis was 57 days. Methotrexate was given systemically (4 x 50 mg i.m.). Because of persisting viability of the fetus, systemic methotrexate treatment was followed by local instillation of methotrexate into the gestational sac (50 mg). Follow-up revealed rapid human chorionic gonadotrophin regression but slow regression of fetal remnants.

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