Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 Mar 15;33(3):298-9.
doi: 10.1007/BF02002789.

The effects of acetylation on the binding region of cartilage proteoglycans to hyaluronic acid

G Quintarelli, A Vocaturo, R Zito, L Rodén

The effects of acetylation on the binding region of cartilage proteoglycans to hyaluronic acid

G Quintarelli et al. Experientia. .

Abstract

Proteoglycans in cartilage are found as aggregates and as monomers. Evidence has been obtained indicating that hyaluronic acid, normally present in this tissue, binds together monomers into large molecular weight aggregates. In this investigation, the interacting region of the protein backbone has been studied. The results unequivocally demonstrated that the epsilon amino groups of lysine are involved in hyaluronic acid binding to proteoglycans and that their blocking by acetylation either prevents reaggregation or disaggregates the high mol.w aggregates.

PubMed Disclaimer

References

    1. J Biol Chem. 1974 Jul 10;249(13):4250-6 - PubMed
    1. Biochem J. 1973 Dec;135(4):905-8 - PubMed
    1. Biochim Biophys Acta. 1972 Sep 15;279(2):401-5 - PubMed
    1. Anal Biochem. 1962 Oct;4:330-4 - PubMed
    1. Am J Anat. 1974 Jul;140(3):433-8 - PubMed

Publication types