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. 1977 Apr 15;36(2):213-8.
doi: 10.1007/BF00273260.

UV-light induced sister chromatid exchanges in xeroderma pigmentosum lymphocytes

A D Schönwald, E Passarge

UV-light induced sister chromatid exchanges in xeroderma pigmentosum lymphocytes

A D Schönwald et al. Hum Genet. .

Abstract

Cultured lymphocytes from 9 patients with clinically different types of xeroderma pigmentosum were exposed to ultraviolet light at 24 h. An increased rate of sister chromatid exchanges were observed in 6 patients (128--148% increase in three, 34--51% in three), but not in three patients with deSanctis-Cacchione syndrome (xeroderma pigmentosum with mental defect), compared to simultaneously cultured controls. A positive result could be useful as preliminary cytogenetic diagnostic test. The results are interpreted as an expression of UV-light induced chromosomal instability due to impaired DNA repair.

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