Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1995 Dec;41(6):721-6.
doi: 10.1007/BF00173151.

Substitution rates in hepatitis delta virus

J Krushkal  1 , W H Li
Affiliations
Review

Substitution rates in hepatitis delta virus

J Krushkal et al. J Mol Evol. 1995 Dec.

Abstract

Substitution rates were estimated for the coding and noncoding regions of the hepatitis delta virus (HDV). The estimated rates of synonymous substitution in HDV were lower than the rates of substitution at non-synonymous sites and in the noncoding region. HDV has lower synonymous substitution rates than the hepatitis C virus, though both are RNA viruses. The relatively low rate of synonymous substitution in HDV may be due to a strong preference of G and C nucleotides at third codon positions. Variation in substitution rate among HDV lineages may be correlated with the clinical development of the HDV-induced hepatitis. The phylogenetic tree inferred for 24 HDV strains reveals similarities between lineages isolated from the same geographic region.

PubMed Disclaimer

References

    1. Gene. 1991 May 30;101(2):251-4 - PubMed
    1. J Med Virol. 1991 Aug;34(4):268-79 - PubMed
    1. J Mol Evol. 1993 Jan;36(1):96-9 - PubMed
    1. Mol Biol Evol. 1988 Jul;5(4):313-30 - PubMed
    1. Mol Biol Evol. 1987 Jul;4(4):406-25 - PubMed

Publication types