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Review
. 1995 Dec;164(6):383-9.
doi: 10.1007/BF02529735.

Molecular mechanisms of endotoxin activity

J Schletter  1 , H Heine, A J Ulmer, E T Rietschel
Affiliations
Review

Molecular mechanisms of endotoxin activity

J Schletter et al. Arch Microbiol. 1995 Dec.

Abstract

Endotoxin (lipopolysaccharide, LPS), a constituent of the outer membrane of the cell wall of gram-negative bacteria, exerts a wide variety of biological effects in humans. This review focuses on the molecular mechanisms underlying these activities and discusses structure-function relationships of the endotoxin molecule, its interaction with humoral and cellular receptors involved in cell activation, and transmembrane and intracellular signal transduction pathways.

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