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. 1996 Mar;12(3):303-8.
doi: 10.1038/ng0396-303.

BRCA1 is secreted and exhibits properties of a granin

R A Jensen  1 , M E Thompson, T L Jetton, C I Szabo, R van der Meer, B Helou, S R Tronick, D L Page, M C King, J T Holt
Affiliations

BRCA1 is secreted and exhibits properties of a granin

R A Jensen et al. Nat Genet. 1996 Mar.

Abstract

Germline mutations in BRCA1 are responsible for most cases of inherited breast and ovarian cancer. However, the function of the BRCA1 protein has remained elusive. We now show that BRCA1 encodes a 190-kD protein with sequence homology and biochemical analogy to the granin protein family. Interestingly, BRCA2 also includes a motif similar to the granin consensus at the C terminus of the protein. Both BRCA1 and the granins localize to secretory vesicles, are secreted by a regulated pathway, are post-translationally glycosylated and are responsive to hormones. As a regulated secretory protein, BRCA1 appears to function by a mechanism not previously described for tumour suppressor gene products.

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Comment in

  • Granin expectations in breast cancer?
    Steeg PS. Steeg PS. Nat Genet. 1996 Mar;12(3):223-5. doi: 10.1038/ng0396-223. Nat Genet. 1996. PMID: 8589705 No abstract available.
  • BRCA1 protein products: antibody specificity..
    Wilson CA, Payton MN, Pekar SK, Zhang K, Pacifici RE, Gudas JL, Thukral S, Calzone FJ, Reese DM, Slamon DI. Wilson CA, et al. Nat Genet. 1996 Jul;13(3):264-5. doi: 10.1038/ng0796-264. Nat Genet. 1996. PMID: 8673120 No abstract available.
  • . . . and secreted tumour suppressors.
    Diamandis EP. Diamandis EP. Nat Genet. 1996 Jul;13(3):268; author reply 269-72. doi: 10.1038/ng0796-268a. Nat Genet. 1996. PMID: 8673122 No abstract available.
  • . . . and secreted tumour suppressors.
    Bradley A, Sharan SK. Bradley A, et al. Nat Genet. 1996 Jul;13(3):268-9; author reply 269-72. doi: 10.1038/ng0796-268b. Nat Genet. 1996. PMID: 8673123 No abstract available.

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